Serum adiponectin levels and inflammatory markers in patients with end-stage renal disease
- VernacularTitle:终末期患者血清脂联素水平及与炎症因子的相关性研究
- Author:
Hua ZHANG
;
Ning JIA
;
Qing XUE
;
Junli GUO
;
Huitao ZHANG
;
Youyou WANG
;
Wenying ZHOU
- Publication Type:Journal Article
- Keywords:
Kidney failure,chronic;
Intercellular signaling peptides and proteins;
C-reactive protein;
Tumor necrosis factor;
Kid-ney function tests
- From:
Journal of Chinese Physician
2008;10(10):1348-1350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the levels of serum adipunectin (ADPN)in patients with end-stage renal disease (ESRD), and identify the relationship between serum ADPN and tumor necrosis factor (TNF)-α, high sensitivity C-reactive protein(hs-CRP) and renal function. Methods Sixty ESRD patients and twenty normal healthy persons were involved in this study. The patients were divided into three groups: patients with chronic renal failure (CRF, 18 cases), patients with hemodialysis (HD,22 cases) and patients with peritoneal dialysis (PD,20 cases). The levels of serum ADPN, TNF-α and hs-CRP were detected by means of ELISA. Differences in continuous variables be-tween the three groups were evaluated. Results The levels of serum ADPN, TNF-α and hs-CRP in CRF, HD and PD patients were signifi-cantly higher than those in control group ( P<0.01 ). Serum ADPN levels in ESRD patients were positive related to serum TNF-α( r≥0.478, P<0.01 ), and negative related to GFR ( r≥-0.582, P<0.01 ). Conclusion The level of serum ADPN was markedly in-creased in patients with ESRD, and correlated with serum TNF-α level and.renal function.
