Effects of Helicobacter pylori infection on plasma lipid in patients with coronary heart disease.
- VernacularTitle:幽门螺杆菌感染对冠心病患者血脂水平的影响
- Author:
Hongtao GONG
;
Fenghe DU
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Helicubacter pylori;
Plasma lipid
- From:
Clinical Medicine of China
2008;24(11):1119-1121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Helicohacter pylori infection on plasma lipid levels. Methods HpIgG was measured by ELISA in both 242 patients with coronary heart disease (CHD) and 88 subjects without CHD, and compared between these two groups. Then 242 patients with CHD were divided into HpIgG positive group and HpIgG negative group ,and total cholesterol (TC) ,triglyceride (TG) ,high density lipaprotein (HDL), low density lipoprotein (LDL), apolipoprotein A (ApoA) , apolipoprotein B (ApoB) were analyzed and compared between these two subgroups. Results The rate of seropositivity for HpIgG in CHD patients was significantly higher than that of controls (53.3 % vs. 38.6 %, P < 0.05), and HDL, ApoA level in HplgG seropasitive group was signif-icantly lower than that of HpIgG seronegative one (P < 0.05). However, there was no difference of TC, TC, LDL and ApoB between these two subgroups (P > 0.05). Conclusion Hp infection may be associated with CHD. It may pro-mote the pathogenesis of CHD through lowering serum HDL-C level.
