Evaluation on short-term prognosis of hepatitis B patients with acute-on-chronic liver failure using MELD and PT
- VernacularTitle:MELD与PT对乙型肝炎慢加急性肝衰竭患者短期预后的评价
- Author:
Jian ZHOU
;
Junmao YE
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
liver failure;
Model for end-stage liver disease;
Prothrombintime;
Prognosis
- From:
Chinese Journal of Clinical Infectious Diseases
2008;1(4):207-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the model for end-stage liver disease (MELD) and PT in survival prediction of hepatitis B patients with acute-on-chronic liver failure. Methods One hundred and thirty-nine hepatitis B patients with acute-on-chronic liver failure were divided into survival and death group, and evaluated by MELD and FT. The area under ROC curve was used to compare the MELD and PT. The mortality was observed within 3 months. Results The MELD score and PT of survival group was 25.09 ± 3.92 and (26.46 ± 6.46) seconds respectively, and those for the death group were 36.25 ± 6.42 and (40.78 ± 10.80) seconds. The differences were of statistical significance ( P < 0.01 ). MELD score showed significant correlations with PT(r =0.824, P <0.01). The area under ROC curve was 0.936 (95% CI 0.895 ± 0.977 ) on MELD score and 0. 890 (95 % CI 0.839 ± 0.941 ) on PT, and there was no significant difference between them. Conclusions Both MELD score and PT can accurately predict the short-term prognosis of hepatitis B patients with acute-on-chronic liver failure. The validity of prognosis by MELD is similar to PT. The mortality increases with the MELD score and PT increasing.
