ADC type cephalosporinase gene in multidrug-resistant strains of Acinetobater baumannii
- VernacularTitle:多药耐药鲍曼不动杆菌ADC型AmpC酶基因研究
- Author:
Jianming ZHU
;
Rujin JIANG
;
Jinlan WU
;
Kangle WU
;
Jianmin WANG
;
Haishen KONG
- Publication Type:Journal Article
- Keywords:
Acinetobuter baumannii;
Drug resistance,multiple;
Cephalosporinase;
ADC type
- From:
Chinese Journal of Clinical Infectious Diseases
2008;1(4):222-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate ADC type cephalosporinase genes in muhidrug-resistant strains of Acinetobater baumannii (MDR-ABA). Methods Sixty-two ABA strains were collected during November 2007 to February 2008 from the First Affiliated Hospital, College of Medicine, Zhejiang University. Kirby Bauer disk diffusion method was used to detect the susceptibilities of the strains to antimicrebial agents. PCR and DNA sequencing was performed to analyze the ADC type cephalosporinase gene. Results Sixty-two MDR-ABA strains showed high drag-resistance rate to most antimicrobial agents expect cefoperazone/sulbactam (69.4%), and 36 strains were ACD positive (58.1%). Conclusion MDR-ABA strains in this study are of high drug resistance, which is closely related to ADC type cephalosporinase.
