Research of chitosan nanoparticles loaded with gene
- VernacularTitle:载基因壳聚糖纳米粒的研究
- Author:
Huiping ZHAO
;
Fen GAO
;
Chuanshi XIAO
- Publication Type:Journal Article
- Keywords:
RNA interference;
Chitosan;
Nanoparticles;
Plasmid CS-NP compounds
- From:
International Journal of Biomedical Engineering
2008;31(5):284-286
- CountryChina
- Language:Chinese
-
Abstract:
The technique of RNA interference has been used in the area of cardiovascular system. Chitosan nanoparticles(CS-NP) has been a hotspot of the research due to its good biological characteristics and has a great potential to be used as the carrier for gene delivery. This article gives a simple review the application of the techniques, the currently used preparation methods of CS-NP, the factors that affect the rate of complexing of plasmid with CS-NP, the transfection efficiency of plasmid CS-NP compounds, and its in vitro drug releasing behavior.
