Efficacy of ultrasound and microbubbles on augmentation phlebothrombosis inrabbit: an in vivo study
- VernacularTitle:诊断超声介导微泡造影剂助溶兔静脉血栓的体内实验研究
- Author:
Ran CHEN
;
Weidong REN
;
Li TANG
;
Xin CHEN
;
Chunyan MA
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Thrombolytie therapy;
Urinary plasminogen activator
- From:
Chinese Journal of Ultrasonography
2008;17(10):895-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of diagnostic ultrasound combined with microbubble contrast agent on augmentation thrombolysis in vivo and to discuss the synergism and mechanism of combination of urokinase. Methods Thirty-two rabbits of femoral vein thrombus were divided into four groups: simple urokinase group, ultrasound and contrast microbubble group, ultrasound and contrast microbubble combined with urokinase group, control group. Then according to the best parameter combination which was definited in previous experiment, the experiments combination of urokinase were performed. Color Doppler was used to evaluate the recanalization of different group in 15 rain,30 min and 60 min. Results After the treatment of 15 rain and 30 min,the recanalization rate in ultrasound and contrast microbubble combined with urokinase group improved significantly compared with other groups (P<0.05);after 60 min, the recanalization grade of ultrasound and contrast microbubble and urokinase group was evidently better than other two group. The result of immunohistochemistry showed that disaggregation of clot and fibrous in this group at 60 min was better than the results at 15 min, 30 min. Conclusions Diagnostic ultrasound with microbubble contrast agent showed superior effects of thrombolysis and the synergism of combination of urokinase in vivo.
