Effects of repeated administrations of 6% hydroxyethyl starch or 7.5% NaCl on cerebral edema after intracerebral hemorrhage in rats
- VernacularTitle:多次给予羟乙基淀粉或高渗氯化钠溶液对实验性脑出血大鼠脑水肿的影响
- Author:
Yuming PENG
;
Lixin AN
;
Baoguo WANG
- Publication Type:Journal Article
- Keywords:
Hetastarch;
Saline solution;
hypertonic;
Brain edema;
Cerebral hemorrhage
- From:
Chinese Journal of Anesthesiology
2008;28(10):905-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of repeated administrations of 6% hydroxyethy] starch (HES) 130/0.4 or 7.5 % NaCl (NS) on brain water content (BWC) after experimental intracerebral hemorrhage (ICH) in rats.Methods One hundred and sixty-seven male SD mrs weighing 260-300 g were randomly divided into 4 groups: group Ⅰ sham operation (S) (n = 20) ;group Ⅱ ICH (n = 38) ;group Ⅲ NS + ICH (n = 55) and group Ⅳ HES + 1CH (n = 54). The animals were anesthetized with intraperitoneal 10% chloral hydrate 400 mg/kg. Experimental ICH was produced by injection of fresh autologous blood 50 μl into right caudate nucleus. In group NS (group Ⅲ) 7.5% NaCl 5 ml/kg and in group HES (group Ⅳ) 6% HES 30 ml/kg were injected at 2, 24, 48 and 72 h after ICH. In group S and ICH (group Ⅰ and Ⅱ) 5 animals were killed at 2, 24, 48 and 72 h after ICH, while in group Ⅲ (NS) and Ⅳ (HES) 5 animals were killed at 2, 24, 48 and 72 h after ICH, immediately before and after NS/HES infusion for determination of ipsilateral and contralateral cerebral cortex and basal ganglion, weight and W/D weight ratio. Rosenberger behavior scores and survival rates were also recorded. Results In group Ⅲ (NS + ICH) and Ⅳ (HES + ICH) the water content of ipsilateral cerebral cortex and basal ganglion was significantly lower than in group Ⅱ (ICH). Rosenberger behavior scores at 24 h and 48 h after ICH were significantly lower in group NS and HES than in group Ⅱ (ICH) . The survival rates at 24, 48 and 72 h after ICH were significandy lower in group Ⅱ than in group NS and HES, especially at 72 h in group HES. Conclusion Repeated administrations of 6% HES 130/0.4 or 7.5% NaCl can ameliorate brain edema after ICH.
