The association between rheumatoid arthritis and single nucleotide polymorphisms of peptidyiarginine deiminase 4 in Han population of Hebei province
- VernacularTitle:肽酰基精氨酸脱亚胺酶4单核苷酸多态性与河北汉族人群类风湿关节炎的相关性研究
- Author:
Zhongjun FENG
;
Shulan ZHANG
;
Yun LIANG
;
Haifeng WEN
;
Yanli NIU
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Polymorphisms,single nucleotide;
Peptidylarginine deiminase 4
- From:
Chinese Journal of Rheumatology
2008;12(11):768-770
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of peptidylarginine deiminase 4 (PADI4) (padi4_94 and padi4_104) genetic single nucleotide polymorphism (SNP) and rheumatoid arthritis (RA) susceptibility in Han population of Hebei province. Methods This hospital-based case-control study included 115 RA patients and 106 healthy controls. All the individuals were recruited from Han Hebei residents and were randomly selected. The genotype and allele frequencies of PADI4 gene polymorphisms (padi4_94 and padi4_104) were analyzed by PCR-DNA sequencing method. Results The distribution of padi4_94 and padi4_104 genotypes between the two groups was not significantly deviated from that expected by Hardy-Weinberg equilibrium (P>0.05). The combined effect of padi4_94 and padi4_104 SNPs was analyzed and three haplotypos (AA, AG and GG) were found but without GA haplotype. The genotype and allele distribution of padi4_94 and padi4_104 in the patients with RA was not significantly different from that in healthy controls,and the analysis of haplotypes revealed that no haplotypes were risk factors for RA. Conclusion In Han population of Hebei province, the SNPs of PADI4 (padi4_94 or/and padi4_104) is no associated with RA susceptibility. Therefore, it should not be regarded as a genetic risk factor for RA.
