Evaluation of rheumatoid factor, anti-cyclic citrullinated peptide antibody and anti-keratin antibody in patients with rheumatoid arthritis
- VernacularTitle:血清抗角蛋白抗体抗环瓜氨酸肽抗体和类风湿因子在类风湿关节炎中的意义
- Author:
Congzhu DING
;
Hong WANG
;
Xuebing FENG
;
Lingyan SUN
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Rheumatoid factor;
,Anti-keratin antibody;
Anti-cyclic eitrul-linated peptide antibody
- From:
Chinese Journal of Rheumatology
2008;12(11):774-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (ACCP) and anti-keratin antibody (AKA) in patients with rheumatoid arthritis (RA).Methods Serum levels of RF, ACCP and AKA were examined in 82 RA and 56 non-RA patients and their sensitivity and specificity for the diagnosis of RA were exmined. Statistical analysis was performed to test the association between ACCP/AKA and number of tender joints and swollen joints, ESR, CRP, disease activity score (DAS) or Ritchie's articular index (RAI). Results ROC curve was performed for each single auto-antibody and various combinations of any two of the above antibodies. The area under the ROC curve was over 0.5 (P<0.05). The specificity of ACCP and AKA was 91.1% and 92.9% respectively. RF, ACCP and AKA were all sensitive markers for the diagnosis of RA and the sensitivity could be as high as 95.1% when one of these markers was positive. There were statistical differences in the number of swollen joints, ESR and DAS between ACCP positive group and ACCP negative group (P<0.05) and statistical significant difference was observed in tender joint count, swollen joint count, ESR and DAS between AKA positive and negative groups (P<0.05). Conclusion Combined test of ACCP, RF and AKA is useful in routine RA diagnosis.ACCP and AKA may be clinical markers for predicting disease activity and prognosis.
