Correlation Analysis of the Expressions of IL-6 , TNF-αand TGF-β in Experimental autoimmune Encephalomyelitis in Rats
- VernacularTitle:FIL-6与TNF-α、TGF-β在EAE大鼠表达的相关性分析
- Author:
Dazhi DUAN
;
Yong LIU
;
Liyun LIANG
;
Cungen MA
- Publication Type:Journal Article
- Keywords:
Encephalomyelitis,experimental autoimmune;
Interleukin-6;
Tumor necrosis factor;
Transforming growth factor beta
- From:
Journal of Chinese Physician
2008;10(10):1314-1317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of IL-6 in EAE. Methods 25 female Wistar rats were randomly divided into 2 groups, EAE group( n=15 ) and normal control group( n=10). The expression of IL-6, TNF-αtand TGF-β of the two groups rots were ob-served by immunohistochemistry staining, and then correlation analysis of the expression of IL-6, TNF-αtandTGF-β was made. Results There was negative correlation between gray scale of IL-6 and symptom scores( r=-0.953, P＞0.05). IL-6 and TGF-β had no statistical-ly significant correlation ( r=-0.492, P＞0.05). There was negative correlation between gray scale of TNF-α and symptom scores( r=-0.978, P＜0.05), and both of the correlation between TNF-α and TGF-β ( r=-0.502, P＞0.05), TGF-β and scores( r=0.470,P＞0.05 ) were not statistically significant. Conclusions IL-6 may participate in EAE as a inflammatory factor.
