Plasma N-terminal pro-brain natriuretic peptide level and its clinical significance in liver cirrhosis
- VernacularTitle:肝硬化患者血浆氨基末端B型尿钠肽前体水平变化及其临床意义
- Author:
Yi TIAN
;
Jin LIU
;
Jiansheng LIU
;
Xiaohong ZHANG
;
Ming MA
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis;
Natriuretic peptide,brain
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(31):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and investigate its relationship with liver function, ascites and heart structure in patients with liver cirrhosis. Methods The levels of plasma NT-proBNP and various clinical and biochemical parameters were determined in 60 patients with liver cirrhosis and 30 healthy controls. Meanwhile Child-Pugh liver function was classified. All people underwent color Doppler echocardiography. Results The level of plasma NT-proBNP was significantly elevated in patients with liver cirrhosis [(38.63±36.05)pmol/L], compared with that of the controls [(7.50±8.25)pmol/L],P<0.01. There was no significant difference in different Child-Pugh class and aseites amount of liver cirrhosis. E/A < 1 and E wave decelerate time (EDT) was in-creased in liver cirrhosis. Conclusion The levels of plasma NT-proBNP in liver cirrhosis are significantly elevated, and related to early impairment of diastolic function. But it does not correlate with liver function and aseites.
