The association between hyperuricemia and prevalence of carotid plaque
- VernacularTitle:高尿酸血症与新发颈动脉粥样硬化斑块的关系
- Author:
Yan LI
;
Dong ZHAO
;
Jing LIU
;
Zhian LI
;
Qiang YONG
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Uric acid;
Coronary atherosclerosis;
Carotid artery diseases;
Cohort studies
- From:
Chinese Journal of Internal Medicine
2008;47(11):906-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association of hyperuricemia with incidence of carotid plaque in general population and furthermore to explore the predictive value of serum uric acid in the early prevention of atherusclerotic disease. Methods The participants were selected from a part of Chinese Multiprovincial Cohort Study (CMCS). Two investigations on cardiovascular risk factors and two on carotid ultrasound detection were carried out in 2002 and 2007, respectively. Results (1) The standard prevalence of hyperurieemia on baseline was 5.4%, being 7.7% in male and 3.9% in female. (2) The standard incidence of carotid plaque was 45.3%, being 51.7% in male and 42. 7% in female. It was shown that the incidence of plaque in the bulb of common carotid arteries was the highest. (3) After adjusting for age, smoking, high triglyceride, high cholesterol, hypertension, diabetes, overweight and obesity,hyperurieemia in female was an independent risk factor associated with 5-year incidence of formation plaque in the bulb of common carotid; the odds ratio (OR) was 3.56 (P = 0.02, 95% CI = 1.21-10. 41).Conclusion Hyperuricemia in female was an independent risk factor associated with 5-year incidence of plaque formation in the bulb of common carotid, and hyperuricemia in male was not an independent factor associated with 5-year incidence plaque formation.
