Prediction of postoperative lung function in patients with lung cancer: preliminary correlative study among quantitative CT, perfusion scintigraphy and anatomical segmentation
- VernacularTitle:定量CT、核素肺灌注及解剖分段法预测肺癌切除术后肺功能对比的初步研究
- Author:
Fang LIU
;
Ping HAN
;
Yongxue ZHANG
;
Fang LIU
;
Jie XIAO
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Tomography,X-ray computed;
Radionuclide;
Respiratory
- From:
Chinese Journal of Radiology
2008;42(11):1179-1182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the accuracy of quantitative CT(QCT), perfusion scintigraphy and anatomical segmentation in predicting postoperative lung function in lung cancer patients. Methods Pulmonary functional tests, quantitative CT scan and perfusion seintigraphy in 12 cases before operation were performed. Forced vital capacity (FVC), the first second forced expiratory volume (FEV1.0) and diffusing capacity of carbon monoxide (DLco) were obtained from preoperative pulmonary functional tests. According to the corresponding formula for QCT, perfusion sintigraphy and anatomical segmentation method, the values of FVC, FEV1.0 and DLco were predicted. The correlation between the predicted values and postoperative values of FVC, FEV1.0 and DLco were assessed. The paired-t test,Pearson correlation test and Bland-Altman analysis were used for the statistics. Results The predicted values of QCT, perfusion sintigraphy and anatomical segmentation method were: FVC [(3.05±0.82), (2.98±0.75) and (2.98±0.86) L,respectively] , FEV1.0[(2.20±0.81), (2.17±0.78) and (2.16±0.84) L, respectively], DLco (FVC: r=0.87, 0.80 and 0.86; FEV1.0:r =0.93, 0.91 and 0.93; DLco:r =0.93, 0.95 and 0.93,respectively,P < 0.01). Conclusion QCT, perfusion sintigraphy and anatomical segmentation method can be used in predicting postoperative lung function. The predicted values are in concordance with the postoperative ones.
