Influence of arterial chemoembolization on expression of Ki-67 in bladder cancer
- VernacularTitle:动脉化疗栓塞对膀胱癌组织中Ki-67表达的影响
- Author:
Rongjiang WANG
;
Sihai SHAO
;
Qilin SHI
;
Hongxing ZHAO
;
Yinyuan ZHENG
;
Hui LI
;
Xiaonong CHEN
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Chemoembolization,therapeutic;
Ki-67 antigen
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(26):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of preoperative arterial chemoembolization on expression of Ki-67,and clinical significance in bladder cancer. Methods Before and after chemoembolizafion of therapy,the expression of Ki-67 in 30 patients of bladder cancer tissue were examined by immunohistochemical staining.The rehtion of its expression to the pathological grade and clinical stage was evaluated clinically.Results Positive rate of Ki-67 expression in the bladder cancer tissue was 70.00% and 26.67% respectively.There was significant difference between the before and after therapy (P＜0.01). Follow-up for mean 24.6 months recurrence rate in 30 cases was 16.67%.The expression of Ki-67 correhted to the pathological grade, clinical stage and patient recurrence rates of bladder cancer.Conclusions Preoperative arterial chemeembelization can reduce the expression of Ki-67,adjust malignancy of bladder cancer,could downgrade and downstage the tumors,and cut down the postoperative metastasis,improve survival rate and reduce recurrence rate.Both of the Ki-67 labeling index are predictive factor for recurrence of superficial bladder cancer.
