Allogeneic hematopoietic stem cell transplantation using Flu/ivBu/TT conditioning regimen for refractory or relapsed acute non-lymphocytic leukemia
- VernacularTitle:FBT预处理方案异基因外周血造血干细胞移植治疗难治/复发急性非淋巴细胞白血病
- Author:
Sanbin WANG
;
Dengming HU
;
Lihui PENG
;
Lin LIU
;
Zhengjun XIE
;
Bo YIN
;
Xiaojuan SUN
- Publication Type:Journal Article
- Keywords:
Thiotepa/TU;
Busulfan/TU;
Vidarabine/TU/AA;
Leukemia,nonlymphocytie,acute/PC;
Transplantation conditioning;
Hematopoietic stem cell transplantation;
Graft vs host disease
- From:
Journal of Chinese Physician
2008;10(10):1300-1302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and feasibility of Flu/ivBu/Tl" conditioning regimen for the treatment of refractory or relapsed acute non-lymphocytic leukemia in patients receiving allogeneic hematopoietie stem cell transplantation. Methods Seven patients with refractory or relapsed acute non-lymphocytic leukemia received HLA identical peripheral blood hematopoietie stem cell transplantation (PBSCT) following Flu/ivBu/TY conditioning regimen, which consisted of fludarbine, busulfex and thiotepa. All patients received cyclos-porin A (CsA) and mycophenolet mofetil (MMF) for prophylaxis of graft - versus - host disease (GVHD). Results The Flu/IVBu/TT regimen was tolerated very well, without severe regimen related toxicity. In the 31-month median follow-up duration, 5 of 7 patients were a-live in disease-free situation. Conclusion The Flu/ivBu/TT conditioning regimen reduced transplantation-related toxicities and offered high long-term disease-free survival, and was tolerated very well. Allogeneie hematopoietie stem cell transplantation using Flu/ivBu/TT condition-ing regimen is a safe and effective option for the patients with refractory/relapsed acute non-lymphocytic leukemia.
