The effect of diltiazem on D860-induced insulin release of rats
- VernacularTitle:地尔硫卓对D860促大鼠胰岛β细胞分泌功能的影响
- Author:
Changqin LIU
;
Shuyu YANG
;
Yuhong CHEN
;
Weiqiong GU
;
Xiaoying LI
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Dihiazem/PD;
Tolbutamide/PD;
Islets of langerhans
- From:
Journal of Chinese Physician
2008;10(10):1330-1332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of diltiazem, one of calcium antagonists, on the function of rat beta cells and the re- lease of insulin induced by D860. Methods Intravenous glucose tolerance test (IVGTY) was conducted to assess beta-cell function of rats among control, dihiazem, D860, and dihiazem plus D860 groups, followed by treatment with dihiazem and D860 for 4 weeks respectively. Another IVGTT was carded out at the end of the study. Results The data showed that diltiazem could inhibit insulin released from normal SD rats. Moreover, it reduced the hypoglycemic effect promoted by D860. However, in long term, the rise of blood sugar in rats treated with D860 respectively was not found. Conclusion Diltiazem did not impair beta cells function and interfere the hypoglycemic effect of D860 in rats in long time.
