The relationship between serum leptin and fibrosis in patients with chronic hepatitis B incorporate alcoholic liver disease
- VernacularTitle:血清瘦素与慢性乙型肝炎合并酒精性肝病肝纤维化的关系
- Author:
Xiping GUO
;
Jida ZHONG
;
Youshun ZHANG
;
Yanling REN
- Publication Type:Journal Article
- Keywords:
Leptin;
Liver cirrhosis;
Liver disease,alcoholic;
Hepatitis B,chronic
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(9):1461-1462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum leptin and fibrosis in chronic hepatitis B incorporate alcoholic liver disease(CHB + ALD) patients.Methods Select 17 male patients with CHB+ALD,15 male patients with liver cirrhosis(LC) ,19 male patients with chronic hepatitis B(CHB) and 12 male healthy persons as normal control(NC).Serum leptin is detected by ELISA in 63 patients.Serum levels of fibrosis markers(HA,LN,PC HI ,IV-C) are determined at the same time.Results Serum leptin level in CHB +ALD are significantly higher than those of the NC(6.79±24.12) μg/L vs (4.27±7.18 ) μg/L (P＜0.05).There is no significant difference between patients with CHB and the NC.The four fibrosis markers in CHB + ALD patients are significantly higher than that of men both in the CHB and the NC.There are significant correlations between both serum leptin level and quadrinomial fibrosis markers(P＜0.05 or P＜0.01 ).Conclusion That serum leptin level is one aecelerate gene in the fibrosis formation in patients with CHB+ALD.
