Application of Pre-S1 antigen in the diagnosis of hepatitis B
- VernacularTitle:前S1抗原检测在乙型肝炎诊断中的应用
- Author:
Zhenping SUN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Pre-S1 antigen;
Virus replication
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(9):1468-1469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze and compare the Pre-S1 antigen and the serum markers to discuss the clinical significance of the Pre-S1 antigen of HBV.Methods The serum markers and the Pre-S1 antigen of HBV were detected by ELISA.Result By analyzing the serum markers in different combination modes,we found that the detection rate of the Pre-S1 antigen in different combination modes are:94% ( in the HBeAg positive mode) ; 15.6%(in the HBeAg negative mode) and negative in the mode both HBsAg and HBeAg are negative.Conclusions The Pre-S1 antigen of HBV has a coherence with HBeAg to a large extent,and has contact relations with the exist and replicate of HBV and can reflect the replication of HBV.The detection of the Pre-S1 antigen can help the diagnosis of HBV infection.
