The expression and significance of EphA7 in pancreatic carcinoma
- VernacularTitle:EphA7在胰腺癌组织中的表达及意义
- Author:
Dequan LI
;
Heshui WU
;
Lin WANG
;
Linfang WANG
;
Chunyou WANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Protein-tyrosine kinase;
EphA7
- From:
Chinese Journal of Pancreatology
2008;8(5):312-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between EphA7 protein and carcinogenesis and development of pancreatic cancer by detecting the expression of EphA7 protein in pancreatic cancer tissues. Methods The expression of EphA7 in 10 cases of normal pancreatic tissue, 51 cases of pancreatic cancer and its adjacent tissues were detected with immunohistechemieal methods and the relationship between EphA7 and pathologic features of pancreatic cancer were analyzed. Results The rate of expression of EphA7 protein in normal pancreatic tissue was 10% (1/10), 47.1% (24/51) in adjacent pancreatic cancer tissues, 94.1% (48/51) in pancreatic cancer tissues. There were significant difference among the three groups (P <0.05). There was no significant correlation between the expression of EphA7 protein and the age, sex, tumor location, tumor size in patients with pancreatic cancer (P > 0.05). However there was significant correlation between the expression of EphA7 protein and the degree of differentiation, clinical staging, lymph node metastasis, or distant metastasis (P < 0.05). Conclusions The abnormally high expression of EphA7 may be relevant with the occurrence and development of the pancreatic cancer.
