Effects of recombinant human growth hormone on myocardial inflammatory eytokine expression and heart function in rats with acute myocardial infarction
- VernacularTitle:重组人生长激素对心肌梗死大鼠心功能及心肌炎性因子表达的影响
- Author:
Shuling RONG
;
Yongjin WANG
;
Xiaolin WANG
;
Fengzhi WANG
;
Gang YANG
;
Yuqin WANG
;
Chao CHANG
;
Heng CAO
;
Yanzhang GAO
;
Yongxin LU
- Publication Type:Journal Article
- Keywords:
Growth hormone;
Myocardial infarction;
Cytokines
- From:
Chinese Journal of Geriatrics
2008;27(10):780-784
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effects of recombinant human growth hormone(rhGH)on myocardial inflammatory cytokine expression and heart function in rats with acute myocardial infarction (AMI). MethodsRats with AMI induced by left anterior descending coronary branch ligation were randomized to rhGH and control groups compared with sham-operated group. The effects of 4 weeks of therapy with GH starting 24 hours after myocardial infarction on myocardial cytokines expression and heart function were studied. Myocardial inflammation was examined by analyzing the myocardial cytokine production including the pro-inflammatory cytokines: interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α and the anti-inflammatory cytokine: IL-10. Echocardiography was used to evaluate heart function. ResultsThe levels of TNF-α, IL-1β, IL-6 and IL-10 in the infarcted and non-infarcted region of control group were markedly elevated compared to sham-operated group (all P＜0.05). After 4 weeks therapy, rhGH reduced the expression of TNF -α, IL-1β, IL-6 and increased IL-10 expression in the infarcted and non-infarcted region of rhGH group compared to control group (all P＜0. 05 ). Echocardiography showed that rhGH markedly improved left heart function (P＜0. 05 ). ConclusionsEarly rhGH treatment can improve heart function and myocardial inflammatory cytokine expression after AMI. One of immunopharmacologic mechanisms underlying the beneficial effects of rhGH on heart function improvement may involve the attenuation of pro-inflammatory cytokines and the increase of anti-inflammatory cytokine levels in cardiac myocytes.
