Clinic research of Iloprost in patients with congenital heart disease associated with pulmonary hypertension
- VernacularTitle:伊洛前列素治疗儿童先天性心脏病并肺动脉高压临床研究
- Author:
Zhiwei WANG
;
Lin YAO
;
Xiaohan YANG
;
Jianzhou GUO
;
Hongtao YU
;
Jihong QIN
- Publication Type:Journal Article
- Keywords:
Iloprost;
Heart defects,congenital;
Hypertension,pulmonary;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(9):1415-1416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of inhaled iloprost (Ventavis) for patients with congenital heart disease associated with pulmonary hypertension.Methods Twenty-two patients with congenital heart disease associated with pulmonary hypertension were selected to inhale Ventsvis by atomizer before surgery ,the required dosage is 25-30ng/(kg.min),aerosolization of iloprest was inhaled by PARI Junior BOY N after diluted with 2ml physiological saline at 3-hour intervals .The change of hemodynamic effects was measured by Doppler ultrasonography after 60min,120min,and 180min.Results The left and fight vemfieular cardiac output at 60min,120min and 180rain after therapy were markedly higher than that before inhaled iloprost ,respirator therapy time was shorter in patients inhaled iloprost.Conclusion inhaled iloprost can increase cardiac output and improve patients cardiac function.Thus,the therapy with inhaled iloprost is effective and feasible.
