Comparative study on the low-dosage methyltestosterone or andriol treatments of senile osteoporosis in men
- VernacularTitle:低剂量甲睾酮和安雄治疗老年男性骨质疏松患者的对比研究
- Author:
Junkun ZHAN
;
Youshuo LIU
;
Tianqi WANG
;
Wu HUANG
;
Limin LONG
;
Yanjiao WANG
;
Yi WANG
;
Eryuan LIAO
- Publication Type:Journal Article
- Keywords:
Methyltestosterone;
Bone mineral density;
Quality of life;
Osteoporosis
- From:
Chinese Journal of Geriatrics
2008;27(10):724-727
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the therapeutic efficacy of low-dosage methyltestosterone or andriol in men with senile osteoporosis. MethodsA total of 134 male patients with senile osteoporosis and the decreased serum level of free testosterone were divided into three groups. 45 patients were treated with low-dosage methyhestosterone(100 mg, once a day, sublingual) and 46 patients were treated with low-dosage andriol (40 mg, once a day, orally), while 43 patients were treated with placebo. The duration of treatment in each group was 1 year. The bone density, blood and urine biochemical indexes related to bone metaholites,the quality of life indexes, ultrasonography for prostate,serum prostate specific antigen,blood routine, urine routine, hepatic and renal function were detected before and after the treatment. ResultsBoth low-dosage methyltestosterone and low-dosage andriol could prevent the decrease of bone mineral density and improve patients' general health, role-emotional function and vitality (all P＜0.05). The difference values of femoral neck bone mineral density before and after treatment with low-dosage andriol and low-dosage methyltestosterone were (0.14+0.18)g/cm2 and (0.12±0.09)g/cm2 , respectively(P＜0.05). Low-dosage andriol hadstronger effects in increasing the level of estradiol (32.5±14.2 )ng/L than low-dosage methyltestosterone(19.3±9.2)ng/L(P＜0.05) and showed more notable effects in improving the physical functioning and role-physical function than low-dosage methyhestosterone. The use of the two androgenic hormones at low dosage showed safety. ConclusionsBoth low-dosage methyltestosterone and low-dosage andriol can be used to treat senile osteoporosis in men and to improve life quality. Both of them are effective and safe therapeutic choices.
