The change of concentration of plasma B-type natriuretic peptide before and after treadmill exercise test and its clinical significance
- VernacularTitle:运动平板试验前后血浆B型尿钠肽浓度的变化及临床意义
- Author:
Jiamin NIU
;
Zhaoling MA
;
Shanglang CAI
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Exercise testing;
Coronary disease
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(31):31-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of the concentration of plasma B-type natriuretic peptide (BNP) before and after treadmill exercise test (TET),and to judge the accuracy of BNP changes ( ABNP)in diagnosing coronary heart disease (CHD). Methods A total of 188 patients with suspected CHD underwent TET and the levels of plasma BNP before and after TET was detected. All the patients were divided into CHD group( group A, n = 96) and non-CHD group(group B, n = 92) according to coronary ar-teriography. Meanwhile, 26 healthy volunteers were enrolled (group C). Results The levels of plasma BNP after TET increased significantly (P<0.01 ). The levels of ABNP of group A were obviously higher than those of group B and C(P<0.01 ). When the levels of △BNP was 8.5 pg/ml, the sensibility, specificity, pos-itive predictive value and negative predictive value of diagnosing CHD was 93.5%, 57.1%, 70.5% and 88.9% respectively. Area under curve (AUC) was 0.815, and 95% confidence interval was 0.768-0.896.Conclusions The levels of plasma BNP after TET increase obviously. It exists higher sensibility and speci-ficity in diagnosing CHD by △ABNP set 8.5 pg/ml.
