The expressions of LL37 and LL37 mRNA in OLP lesions
10.3969/j.issn.1001-3733.2010.01.013
- VernacularTitle:LL37多肽及其mRNA在口腔扁平苔藓病损表达研究
- Author:
Renchuan TAO
;
Jie ZOU
;
Yiping YANG
;
Qixin ZENG
- Publication Type:Journal Article
- Keywords:
Oral lichen planus;
LL-37;
Innate immunity
- From:
Journal of Practical Stomatology
2010;26(1):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of LL37 in oral lichen planus (OLP) lesions. Methods: 25 OLP and 7 health controls were included in this study. IHC and RT-PCR methods were used to detect the LL37 expression on protein level and mRNA level. T-test was used for data analysis. Results: Positive staining of LL37 was found in all the samples in cytoplasm of epithelium cells using IHC method, and mostly in prickle and basal layers. But the reaction intensity in health control was weak, compared to the strong signal in OLP group(P<0.05). The expressions of LL37 mRNA in OLP were significantly higher than those in health controls(P<0.05). Conclusion: The expression of LL37 on normal oral mucosa suggests that it may play a role in maintaining the health of oral mucosa as a part of innate immunity. The up-regulation of LL37 under inflammation status might participate in the immunopathological development of OLP.
