Expression and clinical significance of T regulatory cells in patients with gastric cancer
- VernacularTitle:胃癌患者外周血调节性T细胞的变化及其意义
- Author:
Jingtong WANG
;
Yuanyuan ZHANG
;
Tao PENG
;
Yan WANG
;
Jian YAO
;
Shanshan ZHANG
;
Jiang WU
;
Yulan LIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
T-lymphocytes,regulatory;
Gastritis;
Helicobacter,pylori
- From:
Chinese Journal of General Surgery
2008;23(11):850-852
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the proportion changes of the CD4 + CD25 + T cells and CD8 + CD28 - T cells in the peripheral blood of gastric cancer patients. Methods The proportions of CD4 + CD25 + T cells and CD8 + CD28 - T cells in the peripheral blood of gastric cancer patients were determined by flow cytometry. 30 patients with gastric cancer and 30 patients with chronic gastritis were enrolled in this study. Results Compared with the chronic gastritis controls, the proportion of the CD4 + CD25 + T cells in the peripheral blood of patients with gastric cancer (8.7%±1.3%) was not significantly changed. But the proportion of the CD8 + CD28 - T cell in the peripheral blood of patients with gastric cancer (30.3%±3.3%) was significantly higher than that of control group (20.3%±2.7%), P<0.05. There was no significant association between the proportions of T regulatory cells and the lymphomatic metastasis of gastric cancer. No relation was found between the proportions of T regulatory cells and pathological types of gastric cancer. Conclusion CD8 + CD28 - T ceils in peripheral blood may be of some value in the progression of gastric cancer.
