The research of small dose of estradiol valerate combination of ovseter shell calcium chewable tablets treatment of postmenopausal osteoporosis
- VernacularTitle:小剂量戊酸雌二醇结合牡蛎碳酸钙咀嚼片治疗绝经后骨质疏松症的研究
- Author:
Wangzhe ZHOU
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Estrogen replacement therapy;
Bone density
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(33):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and safety of small dose of estradiol valerate combination of oyster shell calcium chewable tablets treatment of postmenopausal osteoperosis. Methods Thirty-two patients with postmenopausal osteoporosis with oral estradiol valerate 1 mg/d, ovseter shell calcium chewable tablets 150 mg, three times one day, month after serving 15 days added medroxyprogesterone acetate 4 mg/d, at least were observed the course of six months. Results After treatment, bone density of L1-4 and left femur was increased significantly (P<0.05). Twenty-seven cases (84.4%) with six months treatment felt the pain in back and joints improved or disappeared, they could take care of themselves and take part in normal social activities. Four cases of patients within 3 months hod some irregular vaginal bleeding, and service improved after adding modroxyprogesterone acetate, 3 cases of patients with a mild to moderate expansion of mammary gland, one patient appeared leucorrhea increased, but soon turned for better. Conclusions Small dose of estradiol valerate combination of ovseter shell calcium chewable tablets treatment of postmenopausal osteoporosis has the effect of releasing pain, increasing bone density, preventing bone loss, evident result and fewer untoward reaction.
