Correlation of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in gingival crevicular fluid with periodontal inflammation
- VernacularTitle:龈沟液中基质金属蛋白酶-9及基质金属蛋白酶组织抑制剂-1与牙周炎的关系
- Author:
Liwu DONG
;
Chunyan XING
- Publication Type:Journal Article
- Keywords:
Periodontitis;
Matrix metalloproteinase 9;
Immunoblotting;
Gingival crevicular fluid
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(33):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the changes of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-1 (TIMP-1) in gingival crevicular fluid after conventional mechanical therapy of adult patients with chronic periodontitis. Methods Gingival crevicular fluid samples from 15 patients and 15 healthy subjects were taken with filter paper strips by intra-pocket method initially, respectively, 1 month after scaling and root planning. MMP-9,TIMP-1 levels were measured by immunoblotting. Results MMP-9 levels in patients were redueed significantly after treatment[(2.2±1.4)AU vs (1.2±0.9)AU ]. The clinical parameters were positive correlation with MMP-9 level. TIMP-1 levels in patients were increased significantly after treatment[(1.3±1.2)AU vs (3.7±2.2)AU]. The clinical parameters were negative torrelation with TIMP-1 level. Conclusion MMP-9, TIMP-1 levels can act as objective parameters to evaluate the effect of periodontal therapy.
