Change of the serum pro-and anti-inflammatory cytokines in sepsis patients
- VernacularTitle:脓毒症患者血清促炎和抗炎细胞因子的变化
- Author:
Zhenju SONG
;
Shanshan LI
;
Chaoyang TONG
;
Chenling YAO
;
Zhan SUN
;
Peizhi HUANG
- Publication Type:Journal Article
- Keywords:
Sepsis;
Pro-and anti-irflammatory cytokines;
TNF-α;
IL-1;
IL-6;
IL-10
- From:
Chinese Journal of Emergency Medicine
2008;17(11):1191-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of inanune status change in sepsis and severe sepsis patients by quantitative analysing the serum concertrations of pro-and anti-inflammatory cytokines. Method Serum of 38 sepsis patients, 32 severe sepsis patients were collected and 15 health individuals were as controls.ELJSA method was used to quantify the serum levels of inflammatory cytokines. The severity of patient's condition was assessed according to the APACHE Ⅱ system, Retolts The serum concentrations of inflammatory cytokines were different among sepsis and severe sepsis patients. In the serum of sepsis patients the pro-inflammatory eytokine were dominant. But in the serum of severe sepsis patients the anti-inflammatory cytokine were dominant.The serum levels of TNF-α, IL-6, IL-1, IL-10 were obviously different among control, sepsis and severe sepsis groups ( P<0.05). The serum levels of IL-1 and IL-10 were significantly correlated with APACHE II scores. The multiple linear regression eqution was APACHE Ⅱ=- 9.393 + (IL-10 x 0.550) + (IL-1 x 0.305) (F =26.198,P<0.001) Conclusions The serum levels of pro-and anti-inflammatory cytokines were significantly different among patients with different stages of sepsis, and the immune status were different. The activation of inflatrmmtory reaction were constant in sepsis patients, while the expression of anti-inflammatory cytokines increased in severe sepsis patients.
