Thrombolysis through portal vein port-catheter kit for the treatment of portal vein thrombosis
- VernacularTitle:经门静脉导管-皮下药盒系统溶栓治疗门静脉血栓的临床疗效
- Author:
Heping FANG
;
Shuxian CHEN
;
Meihai DENG
;
Weidong PAN
;
Yunbiao LING
;
Ruiyun XU
- Publication Type:Journal Article
- Keywords:
Hypertension,portal;
Vnous thrombosis;
Splenectomy
- From:
Chinese Journal of General Surgery
2008;23(11):832-834
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate a thrombolytic system of portal vein port-catheter kit (PC) in the treatment of portal vein thrombosis (PVT). Methods In this study, 42 PVT patients with liver cirrhosis and portal hypertension after splenectomy from 2005 to 2007 were divided into two groups. In group A (20 eases) thrombolysis was administered through the PC device. Urokinase at the dosage of 1000 U?kg-1?h-1 was given for a consecutive 3 -6 days through the PC, and then the therapy was converted to 100 AxaIU/kg of low molecular heparin twice a day for 7 days subcutaneously. In group B, the thrombolysis was performed on 22 patients through peripheral veins. The therapy was same as in group A except for that the urokinase dosage was doubled. The complete thrombolysis rate, the effective thrombolysis rate, the time of thrombolysis, the long-term recurrence rate and the incidence of complication were compared between the two groups. Results The complete thrombolysis rate and the effective thrombolysis rate in group A were 75%, 90% respectively, compared with that of 41%, 59% respectively in group B. The significant differences in the complete thrombolysis rate, the effective thrombolysis rate, the time of thrombolysis and the incidence of complication were found between the two groups, while the thrombolysis recurrence rate had no significant difference between the two groups. Conclusion PC regime is an effective and safe method for the treatment of portal vein thrombosis.
