The expression of NOD2 and TLR9 in gastric carcinoma and precancerous lesions
- VernacularTitle:胃癌及癌前病变组织中幽门螺杆菌感染与NOD2和TLR9蛋白表达的相关性
- Author:
Bai WEI
;
Youqing ZHU
;
Xiaoyan TANG
;
Wei HOU
;
Yinglan ZHAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasm;
Helicobacter pylori;
Gastric ulcer;
Gastritis,atrophic
- From:
Chinese Journal of General Surgery
2008;23(11):866-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of NOD2 and TLR9 in gastric carcinoma and precancerous lesions and their clinical significance. Methods The expression of NOD2 and TLR9 was measured by immunohistochemical staining (S-P method) in 84 patients with atrophic gastritis, 48 eases with gastric ulcer, 80 cases with gastric adenocarcinoma and 40 eases with superficial gastritis. Results NOD2 and TLR9 expression was up-regnlated in superficial gastritis, atrophic gastritis, gastric ulcer and gastric adenocarcinoma. The positive expression rate of NOD2 was 35% ,21% ,33% ,40% respectively, and the positive expression rate of TLR9 were 15%, 12% ,21% ,22% respectively. The expression of NOD2 and TLR9 in Hp complicated atrophic gastritis, gastric carcinoma was significantly higher than that of lip not complicated disease entities ( P < 0. 05 ). Conclusions The expression of NOD2 and TLR9 may be valuable index for predicting the development of gastric mucosal damage from superficial to atrophic gastritis, gastric ulcer and gastric carcinoma.
