Clinical and pathological characteristics of patients with chronic hepatitis B virus infection in immune tolerant phase
- VernacularTitle:"免疫耐受期"慢性乙型肝炎病毒感染者临床与肝脏病理学特点
- Author:
Jia LI
;
Guiming ZHAO
;
Ying LI
;
Huaibin ZOU
;
Junjuan LIU
;
Limin ZHU
;
Shuren LIANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
DNA,viral;
Liver cirrhosis;
Hepatitis B surface antigen;
Hepatitis B core antigen
- From:
Chinese Journal of Infectious Diseases
2008;26(11):662-665
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and pathological characteristics of patients with chronic hepatitis B virus(HBV)infection in immune tolerant phase.Methods Ninety-eight chronic HBV carriers in immune tolerant phase were enrolled in this study.The age,gender,serum HBV DNA level,hepatic inflammatory activity and fibrosis,hepatic HBsAg and HBcAg expressions were analyzed.The grade of inflammatory activity and stage of fibrosis were also compared in patients with different levels of serum alanine aminotransferase(ALT).Data analysis was done by chi-square test. Results In 98 patients,83(84.7%)were＜30 years old and 15(15.3%)were≥30.Patients whose mother was HBsAg positive were 48.0%.High levels of serum HBV DNA were found in all patients, with 78.5% were＞1×107 copy/mL.Only 5 cases(5.1%)were G0 of the inflammatory grade;whereas,64 cases(65.3%)were G1,29(29.6%)were G2.There were 56 patients(57.1%)had no significant liver fibrosis;and 23 cases(23.5%)were S1,14(14.3%)were S2,5(5.1%)were S3;none of patients had cirrhosis.The HBsAg and HBcAg in liver tissues were positive in 79(80.6%)and 80(81.6%)cases,respectively.The fibrosis stages of patients with higher ALT levels were significantly greater than patients with lower ALT levels(X2=8.112 3,P=0.043 7).Conclusions Most of patients with chronic HBV infection in immune tolerant phase present mild inflammation in liver,some of them have already developed fibrosis.Therefore,liver pathology is recommended for these patients to help understand the patients' conditions and make correct therapeutic decisions.
