MAL gene and its methylation in colorectal carcinoma
- VernacularTitle:MAL基因及其甲基化与大肠癌发生的研究进展
- Author:
Xiaochang WU
;
Guangen YANG
;
Xiujun LIAO
- Publication Type:Journal Article
- Keywords:
colorectal carcinoma;
MAL gene;
tumor-suppressor gene;
DNA methylation
- From:
International Journal of Surgery
2008;35(11):751-754
- CountryChina
- Language:Chinese
-
Abstract:
MAL gene expresses in the mediate and late stage of T-lymphocyte,correlated with carcinoma.Hereditary factors and epigenetic mechanisms play important roles in the pathogenesis of colorectal carcinoma.One of the main epigenetic modifications to be identified is methylation of DNA.the hypermethylation and abnormal expressions of MAL gene play a key role in the development,invasion,metastasis and prognosis of colorectai carcinoma.Therefore MAL gene may be another promising early diagnostic marker,which provide new evidence for early stage prediction,classification,prognosis,chemoprevention of colorectal carcinoma.
