Evaluation of the effect of atorvastatin on neovascularization in the carotid atherosclerotic plaques by contrast enhanced ultrasonography
- VernacularTitle:超声造影评价阿托伐他汀对颈动脉斑块新生血管的影响
- Author:
Shuangshuang NI
;
Pintong HUANG
;
Ying ZHANG
;
Yan YANG
;
Haiyan SUN
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Carotid stenosis
- From:
Chinese Journal of Ultrasonography
2008;17(11):956-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the treatment effect of atorvastatin in patients with soft carotid atherosclerotic plaques using contrast-enhanced ultrasound(CEUS).Methods Sixty patients with acute cerebral infarction and soft carotid atherosclerotic plaques were divided into two groups:high-dose atorvastatin treatment group(40 mg daily)and control group without atorvastatin treatment.The same soft carotid plaque in each patient was examined before and after 3-months'treatment respectively using CEUS.The parameters of CEUS were compared between pretherapy and post-treatment,including arrived time (AT),time to peak(TTP),peak intensity(PI),based intensity(BI)and enhanced intensity(EI,EI=PI-BI).Results EI of carotid plaques in treatment group was decreased significantly than that in control group after three months'treatment(P＜0.05).While the difference of EI in control group has no significance between pre-therapy and post-treatment(P＞0.05). Conclusions The neovascularization in soft carotid plaques was reduced after 3-months'treatment of a high dose atorvastatin.CEUS can be used to evaluate the effect of atorvastatin in treatment of soft carotid plaques.
