Insulin resistance in patients with advanced prostate cancer who received surgical castration
- VernacularTitle:手术去势与晚期前列腺癌患者胰岛素抵抗的相关性研究
- Author:
Xingxing ZHANG
;
Yi LIU
;
Fangyi ZHANG
;
Shengye CHEN
;
Siqi WANG
;
Xiangbin LI
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
Orchiectomy;
Prostate neoplasms;
Insulin resistance
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(33):12-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of insulin resistance in patients with prostate cancer who received surgical castration. Methods Sixty-seven patients with advanced prostate cancer who received with surgical castration were divided into obesity group [30 cases, BMI (26.85±1.22) kg/m2] and non-obesity group[37 cases, BMI(22.72±1.28) kg/m2]. The fasting blood glucose (FBG) and the fasting serum insulin, while evaluated the insulin resistance index(IRI) were determined before treatment, 6 months after treatment and 12 months after treatment. Results The levels of fasting serum insulin were significantly higher 6 months[(23.21±5.78 )mU/L] and 12 months [(24.34±5.37) mU/L] after treatment than that be-fore treatment[(20.01±4.82) mU/L] in obesity group, but 12 months after treatment [(22.19±6.14) mU/L ]was higher than that before treatment [(17.36±6.01) mU/L] in non-obesity group (P<0.01). The IRI were significantly higher 6 months (2.94±0.79) and 12 months (3.10±0.73) after treatment than that be-fore treatment (2.53±0.64) in obesity group, but 12 months after treatment (2.79±0.75) was higher than that before treatmeat(2.17±0.73) in non-obesity group(P<0.01). Conclusion The current data suggests that the patients with prostate cancer who received surgical castration is at risk for developing insulin resistance, thus leading to increasing risk of cardiovascular disease and type 2 diabetes mellitus.
