Relationship between apolipoprotein E ε4,ε2 alleles and intrauterine growth
- VernacularTitle:载脂蛋白Eε4和ε2等位基因与胎儿宫内发育的关系
- Author:
Feng GUO
;
Zhenxin ZHANG
;
Qun XU
;
Junwu ZHANG
;
Hualu ZHAO
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Fetal development;
Apolipoprotein E;
Alleles;
Body mass index
- From:
Chinese Journal of Neurology
2008;41(12):835-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between apolipoprotein E (ApoE) ε4,ε2 alleles and intrauterine growth.Methods ApoE genotypes of 1418 people born in Peking Union Medical College Hospital were analyzed,allele frequencies were calculated and their parameters at birth were collected.To compare ApoE ε4,ε2 alleles with parameters at birth through single factor analysis and Logistic regression analysis.Results The alleLic frequencies of e2,83 and 84 were 8.11%,83.39% and 8.50% in the group.The results of single factor analysis showed that there was significant difference between the distribution of ponderal index (PI) in the ApoE ε2 allele group(χ2=4.87 ,P=0.027).While there was no significant difference between the distribution of head circumference at birth,placental weight and gestational age in the ApoE ε2 allele group.ApoE ε2 allele showed negative correlation with small PI in the logistic regression analysis(χ2=5.077 ,P=0.024),after adjusted for gender,age,head circumference at birth,placental weight,gestational age,parity and maternal age at delivery.No association between ApoE ε4 allele and parameters at birth was found.Conclusions ApoE ε2 allele may have protective effect on PI.No association was found between ApoE ε4 allele and intrauterine growth.
