Progress on colon cancer stem cell
- VernacularTitle:大肠癌干细胞研究进展
- Author:
Zhanhuai WANG
;
Kefeng DING
- Publication Type:Journal Article
- Keywords:
colon cancer;
stem cells;
cancer stem cells
- From:
International Journal of Surgery
2008;35(11):748-751
- CountryChina
- Language:Chinese
-
Abstract:
With advancements in the field of cancer stem cells,the hypothesis that colon cancer originates from stem cells has not only been introduced but also receives substantial supports by separating a subpopulation of colon cancer cells through primitive cells markers.Unlike most non-tumourigenasis colon cancer cells,these tumor-initiating cells have many specific characters both in vitro and in vivo.An improved understanding of drug resistance based on cancer stem cells and molecular pathways that regulate proliferation and differentiation of gastrointestinal cancer stem cells could doubtless translate into new therapeutic strategies.
