Research on Fbx4 protein
- VernacularTitle:Fbx4蛋白质及其研究进展
- Author:
Zhitian WANG
;
Jian HU
- Publication Type:Journal Article
- Keywords:
Fbx4 protein;
SCF Fbx4/αβ-crystallin ligase;
Pin2/TRF1
- From:
International Journal of Surgery
2008;35(12):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Protein degradation mediated by ubiquitin-proteasome pathway is involved in many biological processes.SCF complex is a sort of important E3 ubiquitin-ligase enzyme.Fbx4 protein is one of F-box protein family members,an important component of substrate-specific ScF Fbx4/αβ-crystallin ligase,and a subunit of SCF complex.Inactivation of Fbx4 protein or alteration of its expression level will influence activity of SCF Fbx4/αβ-crystallin ligase,thus will influence expression level of Cyclin D1.And Fbx4 protein is also an important regulatory factor for telomere maintenance.
