Expression of serum sHLA-G in systemic lupus erythematosus
- VernacularTitle:系统性红斑狼疮患者血清中可溶性人类白细胞抗原-G表达水平的研究
- Author:
Jin YANG
;
Xinling YANG
;
Shaolin ZHAO
;
Wei CAO
;
Huiyi WU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Enzyme-linked immunosorbant assay;
Soluble HLA-G
- From:
Chinese Journal of Rheumatology
2008;12(12):839-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum sHLA-G in systemic lupus erythematosus (SLE) patients and the association with the disease activity.Methods The serum concentration of sHLA-G in SLE patients and healthy controls was measured with enzyme-linked immunosorbent assay.Results Significant higher sHLA-G levels were detected in patients of SLE than control group (P＜0.01),The serum concentrations of sHLA-G in active SLE patients were markedly higher than stable SLE patients (P＜0.01).The expression level of sHLA-G showed positive correlations with SLE activity index (SLEDAI)(r=0.30,P=0.01).There was no correlation between sHLA-G levels and serum concentration of Anti-dsDNA,C3,C4 and Anti-ANA in SLE patients (P＞0.05).Conclusion The level of serum sHLA-G is significantly increased in SLE patients.Positive correlations are observed between sHLA-G levels and SLEDAI.These data indicated that sHLA-G may play certain roles in the pathogenesis and progress in SLE.
