Observation on cold-stored rat Hver flushed with self-designed multi-organ preservation solution
- VernacularTitle:自制多器官保存液对大鼠肝脏保存的效果
- Author:
Xiaomin SHI
;
Youhua ZHU
;
Zhiren FU
;
Guoshan DING
;
Zhengxin WANG
;
Wenyuan GUO
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Organ preservation solution;
Rat
- From:
Chinese Journal of Digestive Surgery
2008;7(6):442-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of serf-designed multi-organ preservation solution(SMO)on cold-stored rat liver.Methods The rat livers were preserved with SMO solution(group A,n=15),UW solution(group B,n=15)and HC-A solution(group C,n=15),respectively.The livers were transplanted orthotopically after 6-,12-,24-hour preservation.The changes of liver function at hour 12 after transplantation were detected and conditions of the survived rats at day 14 after transplantation were observed.Results There was no morphological change of the livers in group A within 24 houm.The total bilimbin,alaninetransaminase,and hyaluronic acid increased in group A and B as the preservation time increased,but the levels of the 3 indexes of group A were significant lower than those in group C(F=49.027,70.280,34.349,71.532,446.544,303.408,P＜0.05).No rat djed in group A 14 days after liver transplantation.Conclusions SMO and UW solution have similar effect on protecting the liver.and the protective effect of the 2 solutioas was better than that of HC-A solution.
