Clinical significance of plasma TNF-α and ET levels in patients with subarachnoid hemorrhage
- VernacularTitle:蛛网膜下腔出血患者血浆肿瘤坏死因子-α和内皮素含量动态变化及其临床意义
- Author:
Sibei JI
;
Xiaojun TIAN
;
Hehua LI
;
Zhixiu SONG
;
Kaihua ZHAI
;
Mingxin MA
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Tumor necrosis factor alpha;
Endothelin
- From:
Clinical Medicine of China
2008;24(12):1188-1190
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the plasma TNF-α and endothelin (ET) levels in patient with subarach-noid hemorrhage(SAH). Methods The plasma TNF-α and ET levels were measured by ELISA and radioimmunity at 1,3,7,14 and 21 d after onset of SAH in 45 patients. Results The plasma TNF-α and ET levels in patients with SAH were higher than the normal controls(P<0.01),among which the highest levels appeared at 3 d and 7 d,and the levels of plasma TNF-α and ET in patients with SAH were decreased at 14 d. Those of high Hunt-Hess grade～groups was higher than those of lower grade～groups(P<0.01). Conclusion The plasma TNF-α and ET levels are significantly elevated in the patients with SAH,which suggests that TNF-α and ET may play an important role in the pathogenesis of SAH,and which suggests that is one of the possible ways to prevent and treat cardiovascular spasm (CVS) after SAH by inhibiting TNF-α and ET.
