Role of gastroesophageal reflux disease in exacerbations of chronic obstructive pulmonary disease
- VernacularTitle:胃食管反流病在慢性阻塞性肺疾急性加重中的作用
- Author:
Degan LU
;
Xiaoqing JI
;
Gaiping MA
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Gastroesophageal reflux;
Exacerbation
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(34):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of gastroesophageal reflux disease(GERD)on exacerbations of chronic obstructive pulmonary disease(COPD).Methods All of 74 patients with COPD accomplishing the reflux diagnostic questionnaire(RDQ)were.divided into GERD group(n=38)and non-GERD group(n=36)according the scores of RDQ.The clinical data including the frequency of exacerbations of COPD were compared between the two groups.Results The frequency of exacerbations of COPD was significantly higher in GERD group compared with that in non-GERD group[(2.68±0.77)times/year vs (1.38±0.49)times/year,t=8.74,P＜0.05].The mean FEV;percentage was similar in the two groups [(39.82 4-10.95)%vs(37.11±12.24)%,t=1.00,P＞0.05].The score of RDQ was probably as a factor of predicting the frequency of exacerbations of COPD(R2a=o.39,t=6.98,P＜0.05).Conclusion The presence of GERD appears to be associated with increased exacerbations of COPD.
