Protective mechanism of hepatic ischemic postconditioning
- VernacularTitle:肝脏缺血后处理的保护作用机制
- Author:
Fei SONG
;
Kun LI
;
Zhong ZENG
- Publication Type:Journal Article
- Keywords:
liver;
ischemic postconditioning;
protective mechanism
- From:
International Journal of Surgery
2008;35(12):826-828
- CountryChina
- Language:Chinese
-
Abstract:
lschemic postconditioning(IPo)is a way that after long ischemia on liver graft,animals are given one or several brief reperfusion-ischemia before persistent reperfusion to improve the hepatic tolerance and relieve the ischemie reperfusion injury.It has been proved an effective and controlled method to attenuate the ischemic reperfusion injury.Protective mechanism of ischemic postconditioning on hepatic graft is related with protecting sinus hepaticus endotheliocyte and hepatic microcirculation,relieving hepatic cells injury and inflammatory reaction induced by oxygen free radicals,relieving calcium ovedoad in hepatic cells and mitochondria,regulating apoptosis genes,transforming ion channels condition in mitochondria.This article will makes a brief review on protective mechanism ofhepatic ischemic posteanditioning.
