Recepteur d'origine nantais(RON)in tumor pathogenesis and development
- VernacularTitle:酪氨酸激酶受体RON在肿瘤发生和发展中的作用
- Author:
Hong WANG
;
Kun ZHOU
- Publication Type:Journal Article
- Keywords:
RON;
macrophage stimulating protein;
cancer;
receptor tyrosine kinase
- From:
International Journal of Surgery
2008;35(12):844-847
- CountryChina
- Language:Chinese
-
Abstract:
Tyrosine kinase receptors mediate many critical cellular functions that contribute to tumor progression and metastasis.Recepteur d'origine nantais(RON)belongs to a subfamily of receptor tyrosine kinases(RTK)with unique expression patterns and biological activities.RON is activated by a serum-derived growth factor macrophage stimulating protein(MSP),primarily expressed in cells of epithelial origin.RON activation induced cell transformation,growth,migration and matrix invasion.We review RON molecular structure,activation,and carcinogenic mechanism related.It will contribute to cancel treatment and to discuss RON expression in the tumor.
