Study on correlation of androgen and androgen receptor with coronary heart disease in elderly men
- VernacularTitle:雄激素及其受体与老年男性冠状动脉粥样硬化性心脏病的相关性研究
- Author:
Jian CAO
;
Xiaoying LI
;
Bingpo ZHU
;
Hao WANG
;
Shasha ZHAO
;
Ke MIAO
;
Lan XUE
;
Rongqiang ZHANG
;
Xinli DENG
;
Yu DING
;
Zhiqin GUO
;
Peizhen LI
;
Huiming LI
;
Hui WU
;
Fangling MA
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Gonadal hormones;
Receptor,androgen
- From:
Chinese Journal of Geriatrics
2008;27(12):901-904
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of sex hormone and androgen receptor levels and evaluate the relationship of the sex hormones and androgen receptor with coronary heart disease (CHD) in elderly men. Methods A cross-sectional study was performed in 539 elderly men, including 400 healthy people aged 62-92 years and 139 CHD patients aged 60-88 years. The plasma concentrations of total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured. The androgen receptor (AR) level was tested by flow cytometry. Results The fluorescence intensity of DHEAS, TT, SHBG, FT and AR were significantly lower in CHD group than in healthy group (P<0.01);however, FSH and E2 in CHD group were higher(P(0.01). Age was negatively correlated with TT(r=-0.28,P<0.01) and FT (r=-0.17,P<0.05), and positively correlated with SHBG(r=0.14,P<0.05) and E2 (r=0.33, P<0.01). AR fluorescence intensity was negatively correlated with systolic blood pressure (r=-0.12,P<0.01). Logistic regression analysis indicated that TT (OR=1.065,9% CI: 1.012～1.121,P<0.05), SHBG(OR=0.994,95% CI:0.990～0.998,P<0.01) and AR (OR=0.971,95%CI:0.956～0.986, P<0.01)were significantly associated with CHD in elderly male patients. Conclusions The levels of DHEAS, TT, SHBG, FT and AR are lower in elderly men with CHD than in elderly healthy men;however, the FSH and E2 concentrations are higher. Low levels of TT, SHBG and AR may be the independent risk factors for CHD in elderly men.
