The clinical significance and the expression of JAKs and suppressor of cytokine signaling genes in leukemia cells
- VernacularTitle:JAK家族基因与细胞因子信号传导抑制因子家族基因在白血病细胞中的表达及意义
- Author:
Lin YANG
;
Zhiyun NIU
;
Yuxia PAN
;
Xiaojun LIU
;
Shupeng WEN
;
Xingyan DU
;
Li YAO
;
Jingci YANG
;
Jianmin LUO
- Publication Type:Journal Article
- Keywords:
Leukemia;
Suppressor of cytokine signaling genes;
JAKs
- From:
Clinical Medicine of China
2008;24(12):1196-1199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of suppressor of cytokine signaling genes (SOCSs) and JAKs mRNA in the acute myloid leukemia(AML) patients. Methods The expression of SOCSs and JAKs mRNA as well as TYK2 in AML patients and healthy adults as normal contrals (NC) was measured with RT-PCR. Results The expression of SOCS 1,4,5 and 7 in AML patients was lower than those in normal control and AML with remis-sion (P<0.01),but the expression of SOCS 3 and 6 was higher than those in normal control and remission AML(P<0.01),however there was no significant difference in SOC2 between groups. The expressions of JAK2 ,JAK3 and TYK2 in AML were significantly higher than those in patients with remission and normal control(P<0.05). The ex-pression of JAK1 mRNA in relapsed AML was higher than that in normal control group(P<0.05),but the latter has no statistical significance between beginning treatment and normal group(P>0.05). Conclusion The deletion and degradion of SOCS 1,4,5 and 7 present in AML patients and JAKs expression is significantly increased, suggesting that both of them may co-participate in the pathogenesis of AML.
