Study on the correlation between HLA-DRB1 genes and unexplained recurrent spontaneous abortions in Xiangxi Tujia and Han population
- VernacularTitle:HLA-DRB1基因与湘西土家、汉族人群不明原因反复流产的相关性研究
- Author:
Qiurong CHENG
;
Xuemei LUO
;
Changju ZHOU
;
Jianlin DU
- Publication Type:Journal Article
- Keywords:
Abortion;
HLA-DRB1 gene;
Tujia Minority
- From:
Clinical Medicine of China
2008;24(12):1226-1228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the HLA - DRB1 gene polymorphism and the hereditary association with unexplained recurrent spontaneous abortions(URSA)in a population of Tujia and Han nationality from west part of Hunan province in China. Methods The alleles at the HLA-DRB1 typing were analyzed by polymerase chain reac-tion-sequence specific primers (PCR-SSP) in 76 URSA Tujia population and 68 URSA Han population and 82 healthy Tujia population and 75 healthy Han population. Results ①DRB1*04 frequency of URSA in Tujia and Han population was strikingly higher than that of the healthy Tujia and Han population(RR>1,Pc <0.01),but the DRB1*12 frequency was strikingly lower than that of the healthy Tujia and Han population respectively(RR<1,Pc <0.01). ②DRB1*07 frequency of URSA in Tujia population was strikingly higher than that of the URSA in Han population (18.08% : 5.28%, Pc<0.01). Conclusion HLA-DRB1*04 maybe predisposing genes of URSA in Tujia and Han population,and HLA-DRB1*12 maybe associated with an antagonist effect in the pathogenesis of UR-SA in this population.
