Length of CAG repeat in exon 1 of the androgen receptor gene is associated with the development of acne
- VernacularTitle:雄激素受体基因第一外显子CAG重复序列长度多态性与痤疮的相关性
- Author:
Ying PANG
;
Chundi HE
;
Yong LIU
;
Hong ZHU
;
Bin WEI
;
Kaibo WANG
;
Ning ZHAO
;
Yakun WANG
;
Ting XIAO
;
Yi JIANG
;
Huachen WEI
;
Hongduo CHEN
- Publication Type:Journal Article
- Keywords:
Acne vulgaris;
Receptors,androgen;
Repetitive sequences,nucleic acid;
Polymorphism,restriction fragment length
- From:
Chinese Journal of Dermatology
2008;41(12):796-799
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of CAG repeat length polymorphism in the androgen receptor(AR)gene to the development of acne.Methods A total of 238 patients with ache vulgaris and 207 healthy human controls in Northeast China were included in this study.Genomic DNA was isolated and purified from the blood of these subjects.The CAG repeat lengths in the AR gene were analyzed by somatic microsatellites (STRs).Results A significant difference was found in the CAG repeat number between the male acne Patients(22.70±3.09)and male controls(23.48±2.83,P=0.046),but not between the female cases and controls(23.41±2.87 versus 23.85±0.21.P=0.12).In order to assess the risk associated with CAG repeats,the male and female subjects were dichotomized based on the median repeat length in the corresponding control group as the arbitrary cut-off point.Those men and women with a short CAG repeat length(＜23 in men,and＜24 in women)had a significantly increased risk for agne than those with a long CAG repeat length(men:95%confidence interval,1.21-3.54,OR=2.07,P=0.008;women:95%confidence interval.1.18-3.56,OR=2.05,P=0.01).Conclusions This study strongly indicates that the CAG repeat length in AR gene is associated with the development of acne in Northeast China,and those men with a short CAG repeat length seem to have a high risk for ague.Consequently,CAG repeat length may serve as a genetic susceptibility marker.
