Methylenetetrahydrofolate Reductase Gene Polymorphisms and Ischemic Stroke
- VernacularTitle:亚甲基四氢叶酸还原酶基因多态性与缺血性卒中
- Author:
Fang CHEN
;
Hong ZHENG
;
Yuming XU
- Publication Type:Journal Article
- Keywords:
methylenetetrahydrofolate rednctase;
gene pelymorphism;
ischemic stroke
- From:
International Journal of Cerebrovascular Diseases
2008;16(11):870-875
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have demonstrated that hyperhomocysteinemia is an independent risk factor for stroke,which may cause vascular endothelial injury by multiple mechanisms,destroy blood coagulation and fibrinolytic systems,and influence on lipid metabolism.Methylenetetra hydrofolate reductase(MTHFR)is a key enzyme of homocysteine metabolic pathway in the human body.If it is insufficient or its activity decreases,it will directly result in the accumula tion of homocysteine in the human body,and callse hyperhomocysteinemia.Although a number of studies have found that MTHFR gene mutation is the main cause of MTHFR insufficient and its activity decrease,the correlation between MTHFR gene mutation and ischemic cerebral vascular disease is quite controversial now.This article reviews the relationship between MTHFR gene polymorphisms and ischemic stroke.
