Research status of COX-2 and its inhibitor in breast cancer
- VernacularTitle:环氧合酶-2及其抑制剂与乳腺癌关系研究现状
- Author:
Hui HAN
- Publication Type:Journal Article
- Keywords:
Epoxide hydrolases;
Enzyme inhibitors;
Breast neoplasms
- From:
Journal of International Oncology
2008;35(11):838-840
- CountryChina
- Language:Chinese
-
Abstract:
COX-2 is the rate-limiting enzyme in prostaglandin biosynthesis,which may promote the human tumorigenesis and tumor development through a variety of pathogenic mechanisms.The over expression of COX-2 in breast cancer is significantly correlated with the clinicopathological pammeters and prognosis.COX-2 inhibitors play anti-tumor effects through different mechanisms.Recent studies indicate that COX-2 inhibitors are effective both in breast cancer chemoprevention and treatment of breast cancer combined with cytotoxic drugs and aromatase inaetivators,and therefore may provide a potential new therapy of breast cancer prevention and treatment.
