Relationship between the expression of β-glucuronidase mRNA in hepatocellular carcinoma tissue and the clinicopathologic factors
- VernacularTitle:肝癌组织中β-葡萄糖醛酸酶mRNA与临床病理因素的关系
- Author:
Bo YANG
;
Wenping ZHOU
;
Shunming LI
;
Deting ZHAN
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
β-glucuronidase;
Pathology,clinical
- From:
Chinese Journal of Digestive Surgery
2008;7(6):431-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of β-glucuronidase mRNA in hepatocellular carcinoma(HCC)tissue and the clinicopathologic factors.Methods The expressions of β-glucuronidase mRNA in 25 samples of HCC tissue and 10 samples of normal hepatic tissue were detected by RT-PCR,and the relationship between β-glucurenidase mRNA in HCC tissue and clinicopathologic factors was analyzed.Results The expression of β-glucuronidase mRNA in HCC tissue was not influenced by the age of patient,tumor size and alpha-fetoprotein level.The expression of β-glueuronidase mRNA in patients with portal vein tumor thrombus or lymph node metastasis Was significantly higher than those without(t=7.857,9.341,P＜0.05).Conclusions The expression of β-glucuronidase mRNA is closely related to the existence of portal vein tumor thrombus and lymph node metastasis.β-glucuronidase may play a role in the invasion and metastasis of HCC.
